PT623. A Meta-Analysis of D-Cycloserine Influence ofCognitive-Behavioral Therapy in Obsessive-Compulsive Disorder

Objective: Obsessive compulsive disorder (OCD) is chronic psychiatric disorder with high rate of relapse during the course of illness. It is not well known which factors contribute for the chronicity of the illness, mainly because there are confounding factors as the medication effect. In this study we compared the difference of neurocognitive functions of the first-episode, medication-naive OCD patents to chronic, medication-naïve OCD patients. Method: We defined the first-episode (FEOCD) if the illness duration was less than 3-year by DSM-IV criteria. Twenty one FEOCD and 28 chronic OCD patients performed Korean version of the Wechsler Adult Intelligence Scale (K-WAIS), the Trail Making Test (TMT) and visual memory function test. All the participants were medication-naïve. Results: There was no difference in the severity of illness (YBOCS), depressive symptoms (Hamilton depression rating scale), general anxiety symptoms(Hamilton anxiety rating scale). FEOCD group showed significant better performance on the block design subtest of the K-WAIS (p = 0.04, t = 1.294). There was no significant correlation between the block design scores and the symptoms. Conclusions: These results suggest that visual spatial cognitive dysfunction in patients with OCD may deteriorate as the untreated duration of illness get longer. PT622 The relationship between measures of metacognition, intolerance of uncertainty and obsessive-compulsive disorder Sung Yun Sohn1, Jee In Kang1, Se Joo Kim1 1 Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei Univ. College of Medicine, Seoul, Korea Abstract Introduction: Obsessive-compulsive disorder (OCD) is a severe and incapacitating psychiatric disorder that is characterized by recurrent intrusive thoughts (obsession). Maladaptive metacognition have been found to be associated with anxiety and various psychopathology. Also, intolerance of uncertainty is considered to be related with anxiety and ambivalence. These characteristics are considered to be key characteristics of OCD. Methods: The recruitment includes 52 OCD subjects and 57 healthy controls. All participants completed the metacognition questionnaire (MCQ) and intolerance of uncertainty questionnaire (IOU) as self-report measures. Subjects with OCD completed Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Results: OCD subjects showed significantly higher metacognition score and significantly higher intolerance of uncertainty score than control group. The correlation analysis in OCD group revealed significant correlation between intolerance of uncertainty and obsession measured by Y-BOCS. Conclusion: Need to control thoughts and dysfunctional beliefs about the negative thoughts may represent critical prerequisites for development of obsession.Introduction: Obsessive-compulsive disorder (OCD) is a severe and incapacitating psychiatric disorder that is characterized by recurrent intrusive thoughts (obsession). Maladaptive metacognition have been found to be associated with anxiety and various psychopathology. Also, intolerance of uncertainty is considered to be related with anxiety and ambivalence. These characteristics are considered to be key characteristics of OCD. Methods: The recruitment includes 52 OCD subjects and 57 healthy controls. All participants completed the metacognition questionnaire (MCQ) and intolerance of uncertainty questionnaire (IOU) as self-report measures. Subjects with OCD completed Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Results: OCD subjects showed significantly higher metacognition score and significantly higher intolerance of uncertainty score than control group. The correlation analysis in OCD group revealed significant correlation between intolerance of uncertainty and obsession measured by Y-BOCS. Conclusion: Need to control thoughts and dysfunctional beliefs about the negative thoughts may represent critical prerequisites for development of obsession. PT623 A Meta-Analysis of D-Cycloserine Influence ofCognitive-Behavioral Therapy in Obsessive-Compulsive Disorder Wenjie Gu, Zhen Wang Shanghai Mental Health Center, China HC (N=52) OCD (N=57) Pvalue Mean SD Mean SD